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Forschung

Publikationen

2017

Hawlitschka A, Holzmann C, Witt S, Spiewok J, Neumann AM, Schmitt O, Wree A, Antipova V.:
“Intrastriatally injected botulinum neurotoxin-A differently effects cholinergic and dopaminergic fibers in C57BL/6 mice.”
Brain Res. 2017 Dec 1;1676:46-56. doi: 10.1016/j.brainres.2017.09.016. Epub 2017 Sep 15, PubMed 28919466

Wedekind F, Oskamp A, Lang M, Hawlitschka A, Zilles K, Wree A, Bauer A.:
"Intrastriatal administration of botulinum neurotoxin A normalizes striatal D2 R binding and reduces striatal D1 R binding in male hemiparkinsonian rats.“
J Neurosci Res. 2017 Jul 11. doi: 10.1002/jnr.24110. [Epub ahead of print], PubMed 28695985

Antipova VA, Holzmann C, Schmitt O, Wree A, Hawlitschka A.:
"Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson's Disease Differently Affects Behavior.“
Front Behav Neurosci. 2017 Jun 21;11:119. doi: 10.3389/fnbeh.2017.00119. eCollection 2017. PubMed 28680396

Seidel R, Wree A, Schulze M.:
“Does the approach influence the success rate for ultrasound-guided rectus sheath blocks? An anatomical case series”
Local Reg Anesth. 2017 Jul 5;10:61-65. doi: 10.2147/LRA.S133500, PubMed 28740428

Rabenstein M, Peter F, Joost S, Trilck M, Rolfs A, Frech MJ
"Decreased calcium flux in Niemann-Pick type C1 patient-specific iPSC-derived neurons due to higher amount of calcium-impermeable AMPA receptors."
Mol Cell Neurosci. 2017 Jun 27;83:27-36. doi: 10.1016/j.mcn.2017.06.007, PubMed 28666962

Joost S, Kobayashi K, Wree A, Haas SJ
"Optimisation of murine organotypic slice culture preparation for a novel sagittal-frontal co-culture system.“
J Neurosci Methods. 2017 May 3. pii: S0165-0270(17)30122-X. doi: 10.1016/j.jneumeth.2017.05.003, PubMed 28478074

Kowtharapu BS, Winter K, Marfurt C, Allgeier S, Köhler B, Hovakimyan M, Stahnke T, Wree A, Stachs O, Guthoff RF
"Comparative quantitative assessment of the human corneal sub-basal nerve plexus by in vivo confocal microscopy and histological staining."
Eye (Lond). 2017, 31(3):481-490. doi: 10.1038/eye.2016.220., PubMed 27813513

Schmitt O, Badurek S, Liu W, Wang Y, Rabiller G, Kanoke A, Eipert P, Liu  J (2017)
"Prediction of regional functional impairment following  experimental stroke via connectome analysis."
Sci Rep. 2017 Apr 13;7:46316. doi: 10.1038/srep46316 PubMed 28406178

Malinska A, Podemska Z, Sujka-Kordowska P, Witkiewicz W, Nowicki M, Perek B, Witt M
“Caveolin 2: a facultative marker of unfavourable prognosis in long-term patency rate of internal thoracic artery grafts used in coronary artery bypass grafting. Preliminary report.”
Interact Cardiovasc Thorac Surg. 2017 Jan 25. pii: ivw411. doi: 10.1093/icvts/ivw411., PubMed 28122853

Keiler, J., Schulze, M., Sombetzki, M., Heller, T., Tischer, N. Grabow, T., Wree, A., Bänsch, D.:
"Neointimal fibrotic lead encapsulation – clinical challenges and demands for implantable cardiac electronic devices."
J Cardiol. 2017 Jul;70(1):7-17. doi: 10.1016/j.jjcc.2017.01.011., PubMed 28583688

Seidel R, Gray AT, Wree A, Schulze M
“Surgery of the axilla with combined brachial plexus and intercostobrachial nerve block in the subpectoral intercostal plane.”
Br J Anaesth. 2017 Mar 1;118(3):472-474. doi: 10.1093/bja/aex009, PubMed 28203727

Stahnke T, Kowtharapu BS, Stachs O, Schmitz KP, Wurm J, Wree A, Guthoff RF, Hovakimyan M
“Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro.”
PLoS One. 2017 Feb 23;12(2):e0172592. doi: 10.1371/journal.pone.0172592. eCollection 2017. PubMed 28231275

2016

Wohlert D, Kröger J, Witt M, Schmitt O, Wree A, Czech-Damal N, Siebert U, Folkow L, Hanke FD.:
”A Comparative Morphometric Analysis of Three Cranial Nerves in Two Phocids: The Hooded Seal (Cystophora cristata) and the Harbor Seal (Phoca vitulina).“
Anat Rec (Hoboken). 2016 Mar;299(3):370-8. doi: 10.1002/ar.23298, PubMed 26643122

Schlegel V, Thieme M, Holzmann C, Witt M, Grittner U, Rolfs A, Wree A.:
"Pharmacologic Treatment Assigned for Niemann Pick Type C1 Disease Partly Changes Behavioral Traits in Wild-Type Mice."
Int J Mol Sci. 2016 Nov 9;17(11). pii: E1866., PubMed 27834854

Schulze M., Wree, A.:
„Atemwegsanatomie - Die notfallmedizinisch relevanten Strukturen.“
Notfall Rettungsmed (7/2016) 19: 601. doi:10.1007/s10049-016-0218-x

Seidel R, Zukowski K, Wree A, Schulze M:
”Ultrasound-guided intermediate cervical plexus block and perivascular local anesthetic infiltration for carotid endarterectomy : A randomized controlled trial.“
Anaesthesist. 2016 Oct 14. [Epub ahead of print], PubMed 27742968

Hiemer B, Genz B, Jonitz-Heincke A, Pasold J, Wree A, Dommerich S, Bader R:
”Devitalisation of human cartilage by high hydrostatic pressure treatment: Subsequent cultivation of chondrocytes and mesenchymal stem cells on the devitalised tissue.”
Sci Rep. 2016 Sep 27;6:33747. doi: 10.1038/srep33747, PubMed 27671122

Machado V, Haas SJ, von Bohlen Und Halbach O, Wree A, Krieglstein K, Unsicker K, Spittau B:
"Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease."
Neurobiol Dis. 2016 Apr;88:1-15. doi: 10.1016/j.nbd.2015.12.016 PubMed 26733415

Claassen H, Schmitt O, Wree A, Schulze M:
"Variations in brachial plexus with respect to concomitant accompanying aberrant arm arteries.”
Ann Anat. 2016 Aug 6;208:40-48, PubMed 27507152

Kowtharapu BS, Marfurt C, Hovakimyan M, Will F, Richter H, Wree A, Stachs O, Guthoff RF.
“Femtosecond laser cutting of human corneas for the subbasal nerve plexus evaluation.”
J Microsc. 2016 Aug 19, PubMed 27541992

Langner I, Stahnke T, Stachs O, Lindner T, Kühn JP, Kim S, Wree A, Langner S.
MR microscopy of the human fetal upper extremity - a proof-of-principle study.
BMC Dev Biol. 2016 Jun 18;16(1):21. doi: 10.1186/s12861-016-0123-z. PubMed 27316469

Haas SJ, Zhou X, Machado V, Wree A, Krieglstein K, Spittau B.
Expression of Tgfβ1 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson's Disease.
Front Mol Neurosci. 2016 Feb 3;9:7. doi: 10.3389/fnmol.2016.00007. eCollection 2016. PubMed 26869879

Zeineh MM, Palomero-Gallagher N, Axer M, Gräβel D, Goubran M, Wree A, Woods R, Amunts K, Zilles K.
Direct Visualization and Mapping of the Spatial Course of Fiber Tracts at Microscopic Resolution in the Human
Hippocampus.Cereb Cortex. 2016 Feb 13. pii: bhw010. PubMed 26874183

2015

Neubert J, Bräuer AU.
Superparamagnetic iron oxide nanoparticles: promote neuronal regenerative capacity?
Neural Regen Res. 2015 Oct;10(10):1568-9. doi: 10.4103/1673-5374.165306, PubMed 26692842

Mehlan J, Brosig H, Schmitt O, Mix E, Wree A, Hawlitschka A.
Intrastriatal injection of botulinum neurotoxin-A is not cytotoxic in rat brain - A histological and stereological analysis.
Brain Res. 2015 Nov 10. pii: S0006-8993(15)00844-6. doi: 10.1016/j.brainres.2015.10.056. [Epub ahead of print] PubMed 26562665

Wille M, Schümann A, Wree A, Kreutzer M, Glocker MO, Mutzbauer G, Schmitt O.
The Proteome Profiles of the Cerebellum of Juvenile, Adult and Aged Rats-An Ontogenetic Study.
Int J Mol Sci. 2015 Sep 7;16(9):21454-85. doi: 10.3390/ijms160921454. PubMed 26370973

Wille M, Schümann A, Kreutzer M, Glocker MO, Wree A, Mutzbauer G, Schmitt O.
The proteome profiles of the olfactory bulb of juvenile, adult and aged rats - an ontogenetic study.
Proteome Sci. 2015 Feb 15;13:8. doi: 10.1186/s12953-014-0058-x. eCollection 2015. PubMed 25709559

E. Mick , H. Steinke , T. Wolfskämpf, J. Wieding, N. Hammer, M. Schulze, R. Souffrant, R. Bader.
Influence of short-term fixation with mixed formalin or ethanol solution on the mechanical properties of human cortical bone.
Current Directions in Biomedical Engineering. Band 1, Heft 1, Seiten 335–339, ISSN (Online) 2364-5504, September 2015, DOI: 10.1515/cdbme-2015-0083

Klar M, Fenske P, Vega FR, Dame C, Bräuer AU.
Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro.
Cell Tissue Res. 2015 Sep 9 [Epub ahead of print] PubMed 26350623

Maass F, Petersen J, Hovakimyan M, Schmitt O, Witt M, Hawlitschka A, Lukas J, Rolfs A, Wree A.
Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1 mutant mouse model.
J Neurosci Res 93: 433-442 2015 Mar;93(3):433-42 PubMed 25400034

Pohland M.*, Glumm R.*, Stoenica L., Höltje M., Kiwit J., Ahnert-Hilger G., Strauss U., Bräuer AU., Paul F., Glumm J.
Studying axonal outgrowth and regeneration of the corticospinal tract in organotypic slice cultures.
J Neurotrauma 2015 Jul 14 PubMed 25923828

Neubert J., Wagner S., Kiwit J., Bräuer AU.*, Glumm J.
Effects of different superparamagnetic iron oxide nanoparticles on murine primary brain cells.
International Journal of Nanomedicine, 2015, 10, 2033-2049 PubMed 25792834

Seidel R, Schulze M, Zukowski K, Wree A
Ultrasound-guided intermediate cervical plexus block : Anatomical study.
Anaesthesist. 2015 May 27, PubMed 26013020

Wieding J, Mick E, Wree A, Bader R.
Influence of three different preservative techniques on the mechanical properties of the ovine cortical bone.
Acta Bioeng Biomech. 2015,17(1):137-46. PubMed 25952021

Lehmann R, Gallert C, Roddelkopf T, Junginger S, Wree A, Thurow K.
3 dimensional cell cultures: a comparison between manually and automatically produced alginate beads.
Cytotechnology. 2015, Apr 5. [Epub ahead of print] PubMed 25842191

Voss K, Falke K, Grabow N, Bernsdorf A, Kastner C, Sternberg K, Minrath I, Eickner T, Wree A, Schmitz KP, Guthoff R, Witt M, Hovakimyan M.
Development of a novel injectable drug delivery system for subconjunctival glaucoma Treatment.
J Control Release. 2015 Jul 6. pii: S0168-3659(15)30008-0. PubMed 26160303

Hovakimyan M, Siewert S, Schmidt W, Sternberg K, Reske T, Stachs O, Guthoff R, Wree A, Witt M, Schmitz KP, Allemann R.
Development of an experimental drug eluting suprachoroidal microstent as glaucoma drainage device. 
Transl Vis Sci Technol. 2015 Jun 30;4(3):14. PubMed 26175960

Reetz J, Hildebrandt S, Schmidt A, Meier C, Herchenröder O, Gläser A, Witt M, Pützer BM, Wree A.
Novel subventricular zone early progenitor cell specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity.
Brain Structure & Function 2015 Mar 12. PubMed 25761931

Erdsack N, Dehnhardt G, Witt M, Wree A, Siebert S, Hanke W.
Unique fur and skin structure in harbor seals (Phoca vitulina)—thermal insulation, drag reduction, or both?
J. R. Soc. Interface 12: 20141206. PubMed 25652462

Wree A., Schmitt O.
Basal Ganglia.
In: Arthur W. Toga AW (Ed) Brain mapping: an encyclopedic reference. Elsevier, 2015, pp. 217-227.

2014

Kowtharapu BS, Stahnke T, Wree A, Guthoff RF, Stachs O.
Corneal epithelial and neuronal interactions: role in wound healing.
Exp Eye Res. 2014 Aug;125:53-61. doi: 10.1016/j.exer.2014.05.006. Epub 2014 May 28, PubMed 24880142

Yan X, Ma L, Hovakimyan M, Lukas J, Wree A, Frank M, Guthoff R, Rolfs A, Witt M, Luo J.
Defects in the retina of Niemann-pick type C 1 mutant mice.
BMC Neurosci. 2014, 15(1):126 PubMed 25472750

Schmitt O, Eipert P, Kettlitz R, Leßmann F, Wree A.
The connectome of the basal ganglia.
Brain Struct Funct. 2014, Nov 29. [Epub ahead of print] PubMed 25432770

Prall F, Schmitt O, Schiffmann L.
Tumor regression in rectal cancer after intensified neoadjuvant chemoradiation: a morphometric and clinicopathological study.
World Journal of Surgical Oncology 2015 Apr 21;13:155 PubMed 25896880

Weiss B, Haas S, Lessner G, Mikkat S, Kreutzer M, Glocker MO, Wree A, Schmitt O.
The proteome of the differentiating mesencephalic progenitor cell-line CSM14.1 in vitro.
BioMed Res Int 2014: 1-13. PubMed 24592386

Coiro P., Stoenica L., Strauss U., Bräuer AU.
Plasticity-related gene 5 expression promotes spine formation in primary neurons.
J Biol Chem, 2014, July 29 PubMed 25074937

Hübner A., Derkow K., Bräuer AU.
Efficient isolation of CD8α positive T cells from postnatal mice using a combined MACS approach.
J Immunol Methods, 2014  Apr:406: 110 116 PubMed 24548589

Rupprecht A., Sittner D., Smorodchenko A., Hilse K., Goyn J., Moldzio R., Seiler A., Bräuer AU., Pohl EE.
Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight in their putative function.
PLOS One, 2014 Feb. 11; 9 (2): e88474 PubMed 24523901

Schulz I, Engel C, Niestroj AJ, Kehlen A, Rahfeld JU, Kleinschmidt M, Lehmann K, Roßner S, Demuth HU.
A non-canonical function of eukaryotic elongation factor 1A1: regulation of interleukin-6 expression.
Biochim Biophys Acta. 2014 May;1843(5):965-75. doi: 10.1016/j.bbamcr.2014.01.022. PubMed 24487064

 

 

2013

Antipova V, Hawlitschka A, Mix E, Schmitt O, Dräger D, Benecke R, Wree A.
Behavioural and structural effects of unilateral intrastriatal injections of botulinum neurotoxin A in the rat model of Parkinson’s disease.
Neurosci Res, 2013 Jun;91(6):838-47. PubMed 23553727

Velmans T., Battefeld A., Geist B., Soriguera Farrés A., Strauss U., Bräuer AU.
Plasticity related gene-3 promotes neurite shaft protrusion.
BMC Neuroscience, 2013 Mar 19;14:36 PubMed 23506325

Strauss U. and Bräuer AU.
Current views on regulation and function of plasticity-related genes (PRGs/LPPRs) in the brain. BBA - Molecular and Cell Biology of Lipids.
Special Issue: Lysophospholipids, Biochim Biophys Acta., 2013 Jan;1831(1):133-8 PubMed 23388400

Claassen H, Schmitt O, Schulze M, Wree A.
Variation in the hypothenar muscles and ist Impact on ulnar tunnel Syndrome.
Surg Radiol Anat. 2013 Apr 5 PubMed 23558800

Andressen C.
Neural stem cells: from neurobiology to clinical applications.
Curr Pharm Biotechnol. 2013;14(1):20-28. Review. PubMed 23092257

Andressen C, Wree A.
Cells, micro- and nanosystems in reconstructive medicine: past, present, and future.
Curr Pharm Biotechnol. 2013;14(1):2-3 PubMed 23092253

Buttler D, Mai JK, Ashwell KW, Andressen C.
Clonogenic CD15 immunoreactive radial glial cells from the developing human lateral ganglionic eminence.
Curr Pharm Biotechnol. 2013;14(1):29-35. Pub 23092258

Aktuelle Forschungsvorhaben

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