• Morphologie der Cornea
• experimentelle Glaukomforschung
• Kalorienrestriktion und Verhalten
• Neurale Stammzellen (in vitro und in vivo Studien)
• Neuronale Differenzierungsvorgänge (in vitro und in vivo Studien)
• Zellersatztherapie bei neurodegenerativen Erkrankungen
• Biomechanik der unteren Extremität
• Makroskopische Anatomie, Fort- und Weiterbildung, Kursveranstaltungen
• Klinische Anatomie, Gefäß- und Nervenvarianten des Menschen

• Neurowissenschaftliche Gesellschaft
• Deutsche Anatomische Gesellschaft
• Deutsche Gesellschaft für Wehrmedizin und Wehrpharmazie
• AGIS (Ageing of Individuals and Society), Interdisziplinären Fakultät der Universität Rostock (http://www.inf.uni-rostock.de/)

• Anatomical Record
• Anatomy & Embryology
• Annals of Anatomy
• Cells Tissues Organs
• Experimental Biomedizinische Technik
• Brain Research
• Brain Structure and Function
• Current Pharmaceutical Biotechnology
• Frontiers in Neuroanatomy
• Journal of Anatomy
• Journal of Comparative Neurology
• Journal of Neuroscience Research
• Neuroscience
• Parkinsonism & Related Disorders
• PloS One

• Kowtharapu BS, Winter K, Marfurt C, Allgeier S, Köhler B, Hovakimyan M, Stahnke T, Wree A, Stachs O, Guthoff RF. Comparative quantitative assessment of the human corneal sub-basal nerve plexus by in vivo confocal microscopy and histological staining. Eye (Lond). 2017, 31(3):481-490. doi: 10.1038/eye.2016.220.
• Kowtharapu BS, Marfurt C, Hovakimyan M, Will F, Richter H, Wree A, Stachs O, Guthoff RF. Femtosecond laser cutting of human corneas for the subbasal nerve plexus evaluation. J Microsc. 2017, 265(1):21-26. doi: 10.1111/jmi.12457.
• Stahnke T, Kowtharapu BS, Stachs O, Schmitz KP, Wurm J, Wree A, Guthoff RF, Hovakimyan M. Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro. PLoS One. 2017, 12(2):e0172592. doi: 10.1371/journal.pone.0172592.
• Seidel R, Gray AT, Wree A, Schulze M. Surgery of the axilla with combined brachial plexus and intercostobrachial nerve block in the subpectoral intercostal plane. Br J Anaesth. 2017, 118(3):472-474. doi: 10.1093/bja/aex009.
• Hiemer B, Genz B, Jonitz-Heincke A, Pasold J, Wree A, Dommerich S, Bader R. Devitalisation of human cartilage by high hydrostatic pressure treatment: Subsequent cultivation of chondrocytes and mesenchymal stem cells on the devitalised tissue. Sci Rep. 2016 Sep 27;6:33747. doi: 10.1038/srep33747
• Wille M, Schümann A, Wree A, Kreutzer M, Glocker MO, Mutzbauer G, Schmitt O. The proteome profiles of the cerebellum of juvenile, adult and aged rats-an ontogenetic study. Int J Mol Sci. 2015, 16(9):21454-85. doi: 10.3390/ijms160921454.
• Hovakimyan M, Siewert S, Schmidt W, Sternberg K, Reske T, Stachs O, Guthoff R, Wree A, Witt M, Schmitz KP, Allemann R. Development of an experimental drug eluting suprachoroidal microstent as glaucoma drainage device. Transl Vis Sci Technol. 2015, 30;4(3):14. eCollection 2015 Jun.
• Voss K, Falke K, Bernsdorf A, Grabow N, Kastner C, Sternberg K, Minrath I, Eickner T, Wree A, Schmitz KP, Guthoff R, Witt M, Hovakimyan M. Development of a novel injectable drug delivery system for subconjunctival glaucoma treatment. J Control Release. 2015, 214:1-11.
• Seidel R, Schulze M, Zukowski K, Wree A. [Ultrasound-guided intermediate cervical plexus block. Anatomical study]. Anaesthesist. 2015. 64(6):446-50. German.
• Wieding J, Mick E, Wree A, Bader R. Influence of three different preservative techniques on the mechanical properties of the ovine cortical bone. Acta Bioeng Biomech. 2015,17(1):137-46.
• Lehmann R, Gallert C, Roddelkopf T, Junginger S, Wree A, Thurow K. 3 dimensional cell cultures: a comparison between manually and automatically produced alginate beads. Cytotechnology. 2015, Apr 5. [Epub ahead of print]
• Wille M, Schümann A, Kreutzer M, Glocker MO, Wree A, Mutzbauer G, Schmitt O. The proteome profiles of the olfactory bulb of juvenile, adult and aged rats - an ontogenetic study. Proteome Sci. 2015. 13:8. doi: 10.1186/s12953-014-0058-x. eCollection 2015.
• Wree A., Schmitt O. Basal Ganglia. In: Arthur W. Toga, ed. Brain Mapping: An Encyclopedic Reference. Academic Press: Elsevier; 2015. pp. 217-227.
• Reetz J, Hildebrandt S, Schmidt A, Meier C, Herchenröder O, Gläser A, Witt M, Pützer BM, Wree A. Novel subventricular zone early progenitor cell-specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity. Brain Struct Funct. 2015, Mar 12. [Epub ahead of print]
• Erdsack N, Dehnhardt G, Witt M, Wree A, Siebert U, Hanke W. Unique fur and skin structure in harbour seals (Phoca vitulina)-thermal insulation, drag reduction, or both? J R Soc Interface. 2015 Mar 6;12(104). pii: 20141206.
• Maass F, Petersen J, Hovakimyan M, Schmitt O, Witt M, Hawlitschka A, Lukas J, Rolfs A, Wree A. Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: A mouse model of Niemann-Pick type C1 disease. J Neurosci Res. 2015, 93(3):433-42.
• Yan X, Ma L, Hovakimyan M, Lukas J, Wree A, Frank M, Guthoff R, Rolfs A, Witt M, Luo J. Defects in the retina of Niemann-pick type C 1 mutant mice. BMC Neurosci. 2014, 15(1):126
• Schmitt O, Eipert P, Kettlitz R, Leßmann F, Wree A. The connectome of the basal ganglia. Brain Struct Funct. 2014 Nov 29. [Epub ahead of print]
• Kowtharapu BS, Stahnke T, Wree A, Guthoff RF, Stachs O. Corneal epithelial and neuronal interactions: role in wound healing. Exp Eye Res. 2014, 125:53-61.
• Hovakimyan M, Falke K, Stahnke T, Guthoff R, Witt M, Wree A, Stachs O. Morphological analysis of quiescent and activated keratocytes: a review of ex vivo and in vivo findings. Curr Eye Res. 2014, 39(12):1129-44.
• Yan X, Lukas J, Lin J, Ernst M, Koczan D, Witt M, Fuellen G, Wree A, Rolfs A, Luo J.Aberrant expressions of delta-protocadherins in the brain of Npc1 mutant mice. Histol Histopathol. 2014, 29(9):1185-99
• Yan X, Yang F, Lukas J, Witt M, Wree A, Rolfs A, Luo J. Hyperactive glial cells contribute to axonal pathologies in the spinal cord of Npc1 mutant mice. Glia. 2014, 62(7):1024-40.
• Weiss B, Haas S, Lessner G, Mikkat S, Kreutzer M, Glocker MO, Wree A, Schmitt O. The proteome of the differentiating mesencephalic progenitor cell line CSM14.1 in vitro. Biomed Res Int. 2014, 2014:351821.
• Yan X, Lin J, Talabattula VA, Mußmann C, Yang F, Wree A, Rolfs A, Luo J. ADAM10 negatively regulates neuronal differentiation during spinal cord development. PLoS One. 2014 Jan 3;9(1):e84617. doi: 10.1371/journal.pone.0084617.
• Kuhla A, Hahn S, Butschkau A, Lange S, Wree A, Vollmar B. Lifelong caloric restriction reprograms hepatic fat metabolism in mice. J Gerontol A Biol Sci Med Sci. 2014, 69(8):915-22.
• Hovakimyan M, Meyer A, Lukas J, Luo J, Gudziol V, Hummel T, Rolfs A, Wree A, Witt M. Olfactory deficits in Niemann-Pick type C1 (NPC1) disease. PLoS One. 2013, Dec 31;8(12):e82216. doi: 10.1371/journal.pone.0082216
• Bergt S, Güter A, Grub A, Wagner NM, Beltschany C, Langner S, Wree A, Hildebrandt S, Nöldge-Schomburg G, Vollmar B, Roesner JP. Impact of Toll-like receptor 2 deficiency on survival and neurological function after cardiac arrest: a murine model of cardiopulmonary resuscitation. PLoS One. 2013 Sep 16;8(9):e74944. doi: 10.1371/journal.pone.0074944
• Rudolph A, Eickner T, Seidlitz A, Weitschies W, Wree A, Schmitz KP, Sternberg K. Investigation of in vitro drug release behaviour of drug-eluting stents using a perfusion culture system. Biomed Tech (Berl). 2013 Sep 7. pii: /j/bmte.2013.58.issue-s1-C/bmt-2013-4098/bmt-2013-4098.xml
• Hovakimyan M, Maass F, Petersen J, Holzmann C, Witt M, Lukas J, Frech MJ, Hübner R, Rolfs A, Wree A. Combined therapy with cyclodextrin/allopregnanolone and miglustat improves motor but not cognitive functions in Niemann-Pick Type C1 mice. Neuroscience. 2013, 252:201-11. doi: 10.1016/j.neuroscience.2013.08.001.
• Allemann R, Stachs O, Falke K, Schmidt W, Siewert S, Sternberg K, Chichkov B, Wree A, Schmitz KP, Guthoff RF. New concepts for pressure-controlled glaucoma implants. Ophthalmologe. 2013. 110(8):733-9.
• Kuhla A, Lange S, Holzmann C, Maass F, Petersen J, Vollmar B, Wree A. Lifelong caloric restriction increases working memory in mice. PLoS One. 2013 Jul 10;8(7):e68778. doi: 10.1371/journal.pone.0068778.
• Löbler M, Buß D, Kastner C, Mostertz J, Homuth G, Ernst M, Guthoff R, Wree A, Stahnke T, Fuellen G, Voelker U, Schmitz KP. Ocular fibroblast types differ in their mRNA profiles--implications for fibrosis prevention after aqueous shunt implantation. Mol Vis. 2013, 19:1321-31.
• Zhivov A, Winter K, Peschel S, Stachs O, Wree A, Hildebrandt G, Guthoff R. Changes in the micromorphology of the corneal subbasal nerve plexus in patients after plaque brachytherapy. Radiat Oncol. 2013 Jun 7;8:136. doi: 10.1186/1748-717X-8-136.
• Claassen H, Schmitt O, Schulze M, Wree A. Variation in the hypothenar muscles and its impact on ulnar tunnel syndrome. Surg Radiol Anat. 2013, 35(10):893-9.
• Antipova V, Hawlitschka A, Mix E, Schmitt O, Dräger D, Benecke R, Wree A. Behavioral and structural effects of unilateral intrastriatal injections of botulinum neurotoxin a in the rat model of Parkinson's disease. J Neurosci Res. 2013, 91(6):838-47.
• Schmitt O, Eipert P, Philipp K, Kettlitz R, Fuellen G, Wree A. The intrinsic connectome of the rat amygdala. Front Neural Circuits. 2012, Dec 11;6:81. doi: 10.3389/fncir.2012.00081.
• Gradl G, Herlyn P, Finke B, Gierer P, Wree A, Witt M, Mittlmeier T, Vollmar B. A pan-caspase inhibitor reduces myocyte apoptosis and neuropathic pain in rats with chronic constriction injury of the sciatic nerve. Anesth Analg. 2013,116(1):216-23.
• Hawlitschka A, Antipova V, Schmitt O, Witt M, Benecke R, Mix E, Wree A. Intracerebrally applied botulinum neurotoxin in experimental neuroscience. Curr Pharm Biotechnol. 2013,14(1):124-30.
• Andressen C, Wree A. Cells, micro- and nanosystems in reconstructive medicine: past, present, and future. Curr Pharm Biotechnol. 2013,14(1):2-3.
• Holzmann C, Dräger D, Mix E, Hawlitschka A, Antipova V, Benecke R, Wree A. Effects of intrastriatal botulinum neurotoxin A on the behavior of Wistar rats. Behav Brain Res. 2012, 234(1):107-16.
• Siewert S, Schultze C, Schmidt W, Hinze U, Chichkov B, Wree A, Sternberg K, Allemann R, Guthoff R, Schmitz KP. Development of a micro-mechanical valve in a novel glaucoma implant. Biomed Microdevices. 2012 Oct;14(5):907-20. doi: 10.1007/s10544-012-9670-7.
• Hovakimyan M, Müller J, Wree A, Ortinau S, Rolfs A, Schmitt O. Survival of transplanted human neural stem cell line (ReNcell VM) into the rat brain with and without immunosuppression. Ann Anat. 2012, 194(5):429-35.
• Stahnke T, Löbler M, Kastner C, Stachs O, Wree A, Sternberg K, Schmitz KP, Guthoff R. Different fibroblast subpopulations of the eye: a therapeutic target to prevent postoperative fibrosis in glaucoma therapy. Exp Eye Res. 2012, 100:88-97.
• Bethge A, Schumacher U, Wree A, Wedemann G. Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma. PLoS One. 2012;7(4):e35689. doi: 10.1371/journal.pone.0035689.
• Avchalumov Y, Kirschstein T, Lukas J, Luo J, Wree A, Rolfs A, Köhling R. Increased excitability and compromised long-term potentiation in the neocortex of NPC1(-/-) mice. Brain Res. 2012, 20;1444:20-6.
• Schmitt O, Usunoff KG, Lazarov NE, Itzev DE, Eipert P, Rolfs A, Wree A. Orexinergic innervation of the extended amygdala and basal ganglia in the rat. Brain Struct Funct. 2012, 217(2):233-56.
• Hovakimyan M, Petersen J, Maass F, Reichard M, Witt M, Lukas J, Stachs O, Guthoff R, Rolfs A, Wree A. Corneal alterations during combined therapy with cyclodextrin/allopregnanolone and miglustat in a knock-out mouse model of NPC1 disease. PLoS One. 2011;6(12):e28418. doi: 10.1371/journal.pone.0028418.
• Yan X, Lukas J, Witt M, Wree A, Hübner R, Frech M, Köhling R, Rolfs A, Luo J. Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse. Metab Brain Dis. 2011, 26(4):299-306.
• Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011, 121(10):3924-31.
• Hovakimyan M, Guthoff R, Reichard M, Wree A, Nolte I, Stachs O. In vivo confocal laser-scanning microscopy to characterize wound repair in rabbit corneas after collagen cross-linking. Clin Experiment Ophthalmol. 2011, 39(9):899-909.
• Krüger A, Hovakimyan M, Ramírez Ojeda DF, Stachs O, Wree A, Guthoff RF, Heisterkamp A. Combined nonlinear and femtosecond confocal laser-scanning microscopy of rabbit corneas after photochemical cross-linking. Invest Ophthalmol Vis Sci. 2011, 52(7):4247-55.
• Lazarov NE, Usunoff KG, Schmitt O, Itzev DE, Rolfs A, Wree A. Amygdalotrigeminal projection in the rat: An anterograde tracing study. Ann Anat. 2011, 193(2):118-26.
• Hovakimyan M, Stachs O, Reichard M, Mascher H, Lukas J, Frech MJ, Guthoff R, Witt M, Rolfs A, Wree A. Morphological alterations of the cornea in the mouse model of niemann-pick disease type c1. Cornea. 2011, 30(7):796-803.
• Lange C, Mix E, Frahm J, Glass A, Müller J, Schmitt O, Schmöle AC, Klemm K, Ortinau S, Hübner R, Frech MJ, Wree A, Rolfs A. Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells. Neurosci Lett. 2011, 13;488(1):36-40.
• Wree A, Mix E, Hawlitschka A, Antipova V, Witt M, Schmitt O, Benecke R. Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's disease. Neurobiol Dis. 2011, 41(2):291-8.
• Hovakimyan M, Guthoff R, Knappe S, Zhivov A, Wree A, Krüger A, Heisterkamp A, Stachs O. Short-term corneal response to cross-linking in rabbit eyes assessed by in vivo confocal laser scanning microscopy and histology. Cornea. 2011, 30(2):196-203.
• Dräger DL, Branski RC, Wree A, Sulica L. Friedrich Berthold Reinke (1862-1919): anatomist of the vocal fold. J Voice. 2011, 25(3):301-7.
• Giese AK, Frahm J, Hübner R, Luo J, Wree A, Frech MJ, Rolfs A, Ortinau S. Erythropoietin and the effect of oxygen during proliferation and differentiation of human neural progenitor cells. BMC Cell Biol. 2010 Dec 2;11:94. doi: 10.1186/1471-2121-11-94.
• Reichard M, Hovakimyan M, Wree A, Meyer-Lindenberg A, Nolte I, Junghans C, Guthoff R, Stachs O. Comparative in vivo confocal microscopical study of the cornea anatomy of different laboratory animals. Curr Eye Res. 2010, 35(12):1072-80.
• Lessner G, Schmitt O, Haas SJ, Mikkat S, Kreutzer M, Wree A, Glocker MO. Differential proteome of the striatum from hemiparkinsonian rats displays vivid structural remodeling processes. J Proteome Res. 2010, 9(9):4671-87.
• Yan X, Lin J, Wang H, Markus A, Wree A, Rolfs A, Luo J. Regional expression of the ADAMs in developing chicken cochlea. Dev Dyn. 2010, 239(8):2256-65.
• Hildebrandt S, Schmidt A, Stoll A, Schmitt O, Köhling R, Wree A, Haas SJ, Pützer BM. Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors. Brain Struct Funct. 2010, 215(2):105-13.
• Claassen H, Schmitt O, Werner D, Schareck W, Kröger JC, Wree A. Superficial arm arteries revisited: Brother and sister with absent radial pulse. Ann Anat. 2010, 192(3):151-5.
• Hovakimyan M, Spasova M, Wree A, Schmitt O. In vitro differentiation of the immortalized mesencephalic progenitor cell line CSM14.1 occurs independently from haematopoietic cytokines. Cell Mol Biol (Noisy-le-grand). 2010 Feb 28;56 Suppl:OL1252-60.
• Stachs O, Zhivov A, Kraak R, Hovakimyan M, Wree A, Guthoff R. Structural-functional correlations of corneal innervation after LASIK and penetrating keratoplasty. J Refract Surg. 2010, 26(3):159-67.

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